KMID : 1009020220200010118
|
|
Clinical Psychopharmacology and Neuroscience 2022 Volume.20 No. 1 p.118 ~ p.125
|
|
The Impact of Long-acting Paliperidone in Reducing Hospitalizations and Clinical Severity in Recent Onset Schizophrenia: A Mirror-image Study in Real-world Clinical Setting
|
|
Peitl Vjekoslav
Margetic Branka Aukst Vidrih Branka Karlovic Dalibor
|
|
Abstract
|
|
|
Objective: Schizophrenia is a debilitating disease that disrupts the lives of many affected individuals and exerts a toll on the health system. Only few studies assessed once-monthly injectable formulation of paliperidone palmitate (PP-1M) and other long-acting antipsychotics in recent onset schizophrenia (ROS). To evaluate whether PP-1M is efficacious in reducing frequency and length of hospitalizations and psychosis symptom severity in patients with ROS.
Methods: This mirror-image study included 112 patients, suffering from ROS admitted in a psychiatric ward and successively treated with PP-1M for 1-year. Other psychotic disorders were excluded. We collected socio-demographic data of all subjects included, number and days of hospitalization, as well as Clinical Global Impression-Severity scale (CGI-S) and Clinician-Rated Dimensions of Psychosis Symptom Severity (CRDPSS) scores at the initiation and after 1-year of PP treatment.
Results: After 1-year PP-1M treatment, mean scores of both CGI and CRDPSS significantly decreased (p < 0.001), as well as the mean number of hospitalizations (p = 0.002) and total hospitalization days (p < 0.001) in comparison with those of the previous year.
Conclusion: Our results suggest that PP-1M can be considered as an important therapeutic option in patients with ROS. Its use led to a meaningful reduction in the patient¡¯s use of hospital services, as well as a significant clinical improvement of psychotic symptoms in our sample.
|
|
KEYWORD
|
|
Antipsychotic agents, Paliperidone palmitate, Pragmatic clinical trials, Psychotic disorders
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|